William married Elizabeth Rice on 10 May 1716 in East Greenwich, Kent, Rhode Island. Elizabeth (daughter of John Rice, Jr. and Elnathan Whipple) was born on 6 May 1698 in Warwick, Kent, Rhode Island; died after May 1758 in , , Rhode Island. [Group Sheet] [Family Chart]

1. John Spencer was born on 25 Jan 1716/1717 in East Greenwich, Kent, Rhode Island; died on 11 Nov 1766 in East Greenwich, Kent, Rhode Island.
2. Richard Spencer was born on 16 Mar 1718/1719 in East Greenwich, Kent, Rhode Island.
3. Audrey or Dora Spencer was born on 6 Apr 1720 in East Greenwich, Kent, Rhode Island; died on 4 Sep 1770 in West Greenwich, Kent, Rhode Island; was buried in Isaac Johnson Lot, Bates Trail, West Greenwich, Kent, Rhode Island.
4. William Spencer, Jr. was born on 4 Jul 1723 in East Greenwich, Kent, Rhode Island; died in 1777 in East Greenwich, Kent, Rhode Island; was buried in Straight-Spencer Lot, East Greenwich, Kent, Rhode Island.
5. Ellen Spencer was born on 14 Sep 1725 in East Greenwich, Kent, Rhode Island.
6. Elizabeth Spencer was born on 1 Dec 1727 in East Greenwich, Kent, Rhode Island.
7. Job Spencer was born on 16 Mar 1729/1730 in East Greenwich, Kent, Rhode Island.
8. Nathan Spencer was born on 25 Jun 1732 in East Greenwich, Kent, Rhode Island.
9. Samuel or Randall Spencer was born on 28 Dec 1734 in East Greenwich, Kent, Rhode Island.
10. Benjamin Spencer was born on 28 Jan 1735/1736 in East Greenwich, Kent, Rhode Island.
11. Leah Spencer was born on 14 Sep 1742 in East Greenwich, Kent, Rhode Island.

John married Audry Greene about 1692. Audry was born on 27 Dec 1667; died on 17 Apr 1733. [Group Sheet] [Family Chart]

John + Susanna. [Group Sheet] [Family Chart]